Reproduction Abstracts

Introduction: Maternal androgen excess in pregnant sheep programmes a PCOS-like phenotype in female offspring. We previously demonstrated a hyperinsulinaemic offspring phenotype in response to maternal androgen excess, but such regimens also increase estradiol concentrations, and may effect adrenal steroidogenesis, hence the role of androgens remains unclear.Materials and Methods: To examine contributions of different steroid classes, and to determine if...